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Objectives: The aim of this study was to evaluate the subjective well-being of schizophrenic patients who swit-ched their antipsychotics to risperidone as the maintenance treatment over 24 weeks. Methods: Thirty-one pa-tients were evaluated using Positive and Negative Syndrome Scale (PANSS) for psychopathology and UKU side effects rating scale for drug-induced adverse events. Also the subjects were asked to score the 10 items self-rating scale (KmSWN-lO), which derived from the 19-items of Korean modified version of Subjective Well-being under the neuroleptic treatment (KmSWN) scale. The assessments were administered at baseline, 2 weeks, 12 weeks and 24 weeks after switching to risperidone. Analysis were done using repeated measures of ANOVA. Pearson correlation analysis were also done to assess the correlation between KmSWN-lO and psychopathology and drug induced side effects. Results: There were significant improvements on the scores of KmSWN-lO and reductions on the PANSS and UKU side effect rating scores during the treatment of risperidone. KmSWN-lO was negatively correlated with the total, negative and general psychopathology scales of PANSS at baseline, and also negatively corrleated with total, positive, negative, general psychopathology scales and depressive factor of PANSS scores and total UKU side effects rating scores at 24 weeks of treatment. Conclusion: The results suggest that the maintenance treatment with risperidone positively affected on the subjective well-being of schizophrenic patients due to improvement of psychotic symptoms and decrement of side effects. KmSWN-lO may be more related with negative and general psychopathlogy scales of PANSS in this study. (Korean J Psychovhannacol 2004; 15(3):284- 295)
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